Your DNA Reveals the Risk of Cardiovascular Diseases

A key, non-modifiable risk factor for cardiovascular diseases is genetic predisposition. Early identification of this risk enables targeted prevention strategies. Even in individuals without traditional risk factors for cardiovascular diseases, genetic information can uncover a ‘silent’ predisposition that might otherwise remain unknown until an acute event like a heart attack occurs. Professor Konstantinos Toutouzas, President of the Hellenic Cardiology Society, answers critical questions about genetic predisposition and its role in preventing cardiovascular diseases. The hereditary factor is one of the primary non-modifiable risks for cardiovascular diseases. In conditions such as premature coronary disease, hypertension, or hereditary forms of hyperlipidemia, the genetic factor holds significant importance and may outweigh environmental factors. However, most cases of cardiovascular disease result from the interaction of genes and environment — genetic predisposition combined with lifestyle choices. Knowing your genetic predisposition allows for early detection and more personalized preventive strategies. Polygenic Risk Score (PRS) evaluates an individual’s overall genetic risk based on common genetic variations linked to disease development. This analysis is performed through a simple saliva sample and provides insight into the inherent risk embedded in one’s DNA. A high PRS score indicates statistically higher chances of developing heart disease but does not guarantee it. Healthy lifestyle changes and preventive medication where necessary can significantly mitigate these risks, even in those with high genetic loads.